CrosstalkX is an R package for inferring transcription factor-pathway and pathway-pathway interactions from gene expression data. The framework integrates enrichment-derived gene sets, mutual information-based association measures, and background gene interaction networks. Statistical significance is assessed with permutation-based null models, and genes of interest are prioritized through differential-expression neighborhood enrichment.
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Citation: Menna-Arafat. (2026). Menna-Arafat/Crosstalk: CrosstalkX v.1.0.0 (Version v1.0.0) [Computer software]. Zenodo. https://doi.org/10.5281/zenodo.18652756