Integrated GSE165870 CD34⁺ HSPC transcriptomes with aplastic-anaemia GWAS from FinnGen R13, GCST90473132 and GCST90475783 to determine whether progenitor transcriptional dysregulation converges with inherited disease susceptibility. The framework implemented DESeq2 differential expression, WGCNA co-expression modelling, MungeSumstats/METAL GWAS meta-analysis, MAGMA gene-level association, and pathway/network analysis to prioritize signals supported across independent molecular and genetic layers and assess how immune pressure and constrained HSPC fitness may contribute to aplastic anaemia.